I have issues running quisk with HL2 for a long time. My HL2 worked fine with sparksdr/openhpsdr but quisk never discovered it.
I have now freshly installed win7 64 bit, latest python 2.7, wxpyton and latest quisk today. if I open quisk without any configuration, it starts without any issue. Once I add HL2 config as per this guide by Steve it doesn't start.
I also tried the following C:\Python27\pythonw.exe -vvv WinQuisk.pyw with verbose output and it pops up the below wxpython screen and vanishes in few seconds without letting me see the final error output.
To get the logs use
c:\python27\python.exe quisk.py -a
Also, as per Jim's suggestion, this particular issue was fixed by starting Quisk in ConfigFileRadio, changing the band to 40 Meter (any other supported band by HL other than audio band can work) and restarting quisk to HL2 Radio.